Fig.10.

Cell ablation treatment blocks epilepsy progression. Nestin-CreER^T2, DTr^fl/fl mice were generated to induce expression of the diphtheria toxin receptor among newborn granule cells. Epilepsy was induced using the pilocarpine status epilepticus model. Following one month of 24/7 video-EEG monitoring, animals were treated with saline (SE-control) or diphtheria toxin (SE-ablation). Pre-treatment and post-treatment seizure frequencies (A,B) are shown for SE-control mice (left, black) and SE-ablation mice (middle, red). Each line shows the means±SEM for one animal. (C) Average number of seizure events during each week of recording for SE-control (black) and SE-ablation (red) groups (DT was given during week 5, red arrow). Ablation treatment prevented the dramatic increase in seizure frequency evident in SE-control animals. ^*p < 0.05, ^***p < 0.001.