Fig.2.

KL expression regulates dentate adult neurogenesis. Adult neurogenesis occurs as radial glial-like stem cells progress through a series of protein expression and morphological changes to advance from transient amplifying cells (TAP), to committed neuroblasts, to immature neurons and finally fully mature neurons. KL-deficient brains show premature neurogenic aging with decreased proliferation, decreased number of stem cells and immature neurons, and delayed maturation of immature neurons. KL overexpression increases proliferation and enhances maturation causing a greater number of highly arborized immature neurons to persist long after normal age-related downregulation of adult neurogenesis.