Fig. 6.

Increased specific lysis of HCT116 colorectal cancer cells by anti-CEA-CAR NK-92MI after treatments with NaB and 5-AZA. Retrovirally transduced anti-CEA-CAR NK-92MI were co-cultivated with HCT116 cells. Either NaB (0.1 mM) (a) or 5-AZA (1 μM) (c) treatment significantly enhanced the antigen-specific killing power of anti-CEA-CAR NK-92MI in HCT116 cells. HCT116 cells were also co-cultured with parental NK-92MI cells after treatment with either NaB (0.1 mM) for 10 h (b) or (1 μM) for 72 h (d). Representative data from experiments conducted independently in triplicate are shown. *P <  0.05