Fig. 7.

Increased specific lysis of WiDr colorectal cancer cells by anti-CEA CAR NK-92MI after NaB and 5-AZA treatments. Retrovirally transduced anti-CEA CAR NK-92MI cells were co-cultivated with WiDr cells. Either NaB (0.1 mM) (a) or 5-AZA (1 μM) (c) treatment significantly enhanced the antigen-specific killing power of anti-CEA CAR NK-92MI in WiDr cells. WiDr cells were also co-cultured with parental NK-92MI cells after treatment with either NaB (0.1 mM) for 10 h (b) or 5-AZA (1 μM) for 72 h (d). Representative data from experiments conducted independently in triplicate are shown. *P <  0.05