Table 1.

NaB and 5-AZA-induced resistance to anti-cancer drug-5-FU in HCT116 and WiDr cells

Cell line	Treatment	IC50 of 5-FU (uM) Mean ± SD*	P-value**
HCT116	5-FU	4.39 ± 3.10
	0.1 mM NaB+5-FU	9.40 ± 6.03	<0.05(0.036)
	1 μM 5-AZA+5-FU	11.76 ± 9.05	<0.05(0.020)
WiDr	5-FU	4.67 ± 0.55
	0.1 mM NaB+5-FU	9.20 ± 2.74	<0.001
	1 μM 5-AZA+5-FU	10.81 ± 3.34	<0.001

*Results are presented as mean± SD of three independent experiments, each done in triplicate.

**The groups treated with 5-FU and NaB or 5-FU and 5-AZA were significantly increase IC50 comparing to 5-FU alone treatment group in HCT116 and WiDr cells