Fig. 6.

Effects of inhibitors of CB₁R and CB₂R antagonists on phosphorylation of p38 (a), ERK1/2 (b), and GS expression (a, b) in astrocytes induced by LPS. Astrocytes were pretreated with 1 μM AM281 or AM630 for 1 h before cells were treated with 2-AG and LPS. The protein level of p-p38 (a), p-ERK1/2 (b), and GS were measured by western blotting. Error bars were ± SD. n = 3. *p < 0.05, **p < 0.01, and ***p < 0.001