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. 2018 Aug 3;37:182. doi: 10.1186/s13046-018-0854-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Knockdown of RIF1 inhibits tumourigenicity of EOC cells in vivo. a and b Efficiency of RIF1 stable knockdown (RIF1 KD) in OVCAR3 cells by lentivirus was verified by real-time qPCR (a) and western blot (b) after 30 generations of cell culture. c and d. 2 × 10⁶ RIF1 stable-knockdown and vector control OVCAR3 cells were inoculated subcutaneously into the right and left flanks of nude mice. Tumor weight and volume of xenografts were evaluated. e Representative images of H&E and IHC staining of the resected tumor. f and g IHC analysis showed that RIF1 knockdown reduced the expression of hTERT and decreased the proliferation index Ki67. Data were presented as means ± SD. * P < 0.05, ** P < 0.01