Table 2.
S-IGF-I for patients included by etiology, stroke subtype and severity, respectively
| Mean | Mean | Mean | ||||||
|---|---|---|---|---|---|---|---|---|
| ΔIGF-I | P | Acute IGF-I | P | 3-month IGF-I | P | Age | P | |
| (SD) | (SD) | (SD) | ||||||
| Stroke severity (NIHSS†) | Dunnett, q1 vs. q2-q5 | |||||||
| q1 (mild) | 21.6 (42.0) | N/A | 162.4 (59.5) | N/A | 140.8 (50.0) | N/A | 53.1 (12.5) | N/A |
| N | 82 | 82 | 82 | 82 | ||||
| q2 (minor) | 29.0 (51.0) | ns | 181.9 (67.0) | ns | 152.9 (53.1) | ns | 55.7 (9.9) | ns |
| N | 66 | 66 | 66 | 66 | ||||
| q3 (moderate) | 20.6 (49.5) | ns | 168.1 (63.5) | ns | 147.6 (56.0) | ns | 54.4 (11.1) | ns |
| N | 66 | 66 | 66 | 66 | ||||
| q4 (major) | 28.3 (72.7) | ns | 181.6 (61.8) | ns | 153.4 (53.6) | ns | 58.4 (9.5) | 0.01 |
| N | 73 | 73 | 73 | 73 | ||||
| q5 (severe) | 0.58 (58.5) | 0.04 | 171.7 (62.5) | ns | 171.2 (63.2) | 0.003 | 54.0 (10.7) | ns |
| N | 67 | 67 | 67 | 67 | ||||
| Missing (n) | 0 | 0 | 0 | 0 | ||||
| Subtype (OCSP) | Tukey’s crosswise | |||||||
| Lacunar cerebral infarction (LACI) | 21.1 (37.0) | 0.09-TACI | 163.9 (57.4) | ns | 142.8 (48.5) | **TACI | 56.6 (9.6) | 0.05-POCI |
| N | 113 | 113 | 113 | 113 | ||||
| Partial anterior cerebral infarction (PACI) | 18.1 (47.3) | ns | 172.8 (67.9) | ns | 154.7 (59.5) | ns | 55.0 (11.3) | ns |
| N | 104 | 104 | 104 | 104 | ||||
| Posterior cerebral infarction (POCI) | 30.7 (59.4) | **TACI | 181.6 (65.4) | ns | 150.9 (57.1) | ns | 52.7 (12.2) | 0.11-TACI |
| N | 94 | 94 | 94 | 94 | 0.05-LACI | |||
| Total anterior cerebral infarction (TACI) | −1.5 (68.1) | **POCI | 171.7 (58.4) | ns | 173.3 (57.1) | **LACI | 52.7 (9.3) | 0.11-POCI |
| N | 37 | 0.09-LACI | 37 | 37 | 37 | |||
| Missing (N) | 6 | 6 | 6 | 6 | ||||
| Etiology (TOAST) | Tukey’s crosswise | |||||||
| Large vessel diseaase (LVD) | 20.4 (53.7) | ns | 181.1 (57.0) | *D | 160.8 (57.9) | ns | 59.0 (7.8) | ***D, **Cr |
| N | 51 | 51 | 0.08-CE | 51 | 51 | |||
| Small vessel diseaase (SVD) | 19.1 (39.6) | ns | 161.4 (60.6) | ***D | 142.3 (53.4) | **D | 58.4 (7.2) | ***D, **Cr |
| N | 69 | 69 | 69 | 69 | ||||
| Cardioembolic (CE) | 6.1 (46.2) | ns | 151.2 (53.3) | ***D, 0.08-LVD | 145.1 (51.1) | *D | 55.5)11.6) | *D |
| N | 52 | 52 | 0.15-Cr | 52 | 52 | |||
| Cryptogenic (Cr) | 20.1 (43.3) | ns | 174.1 (60.7) | ***D | 154.0 (53.9) | 0.09 vs. D | 53.1 (11.9) | **LVD/SVD |
| N | 112 | 112 | 0.15-CE | 112 | 112 | |||
| Arterial dissection (D) | 40.1 (95.7) | *CE | 223.7 (63.0) | ***SVD/CE/Cr | 183.6 (66.7) | **-SVD | 48.1 (9.4) | ***LVD/SVD |
| N | 27 | 27 | *LVD | 27 | *CE, 0.09-Cr | 27 | **Cr, 0.14-D | |
| Other/undeterrmined | 26.2 (45.7) | N/A | 172.2 (71.9) | N/A | 146.0 (53.7) | N/A | 54.2 (13.5) | N/A |
| n | 43 | 43 | 43 | 43 | ||||
| Missing (N) | 0 | 0 | 0 | 0 | ||||
P-values less than 0.3 are specified although they are considered being not signicant (ns). * < 0.05, ** < 0.01. *** < 0.001 for Dunnett’s or Tukey’s post-hoc tests as indicated. As we have a slightly different number of included patients, and using NIHSS instead of SSS as it was presented in 2011, we present s-IGF-I (acute, 3-month) for comparison with the present inclusion (n = 354). TOAST = Trial of Org 10,172 in Acute Stroke Treatment [1], OCSP = Oxfordshire Community Stroke Project [4]. All variation shown is given in standard deviations (SD). N/A designates not applicable. †Scoring of neurological function is taken from the original SSS scores and converted to NIHSS (methods)