Table 4.
Examples of active clinical studies with bacteria
| Biological Agent | Bacterium | NCT# | Indication |
|---|---|---|---|
| IL-2 | Salmonella | NCT01099631 | Liver Cancer |
| C. novyi-NT | Clostridium |
NCT00358397 NCT01118819 NCT01924689 |
Solid Tumors |
| APS001F | Bifidobacterium | NCT01562626 | Solid Tumors |
| JNJ-64041757 | Listeria |
NCT02592967 NCT02625857 |
NSCLC Prostate Cancer |
| JNJ-757 | Listeria | NCT03371381 | Lung Cancer |
| pLADD | Listeria | NCT03189030 | Metastatic Colorectal Cancer |
| ADU-623 | Listeria | NCT01967758 | Astrocytic Tumors |
| ADXS11-001 | Listeria |
NCT01598792 NCT01266460 |
Oropharyngeal Cancer Cervical Cancer |
| CRS-207 | Listeria |
NCT01675765 NCT00585845 NCT02575807 |
Malignant Pleural Mesothelioma Adenocarcinoma of the Pancreas Ovarian Cancer |
| GVAX & CRS-207 | Listeria/GVAX | NCT02004262 | Pancreatic Cancer |
In these clinical trials, Listeria do not colonize the tumor microenvironment