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Glycosylation in neurons. N-glycosylation begins in the ER by the addition of a core glycan structure to a nascent protein. Trimming and extension take place throughout the Golgi. In COG-KO cells, N- and O-glycans are undergalactosylated and undersialylated. Neurons have an additional trafficking route that bypasses the Golgi resulting in underglycosylated structures
