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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Curr Opin Physiol. 2017 Dec 23;2:42–50. doi: 10.1016/j.cophys.2017.12.007

Figure 4. Impaired action potential generation in PV and SST interneurons from from Cre+ mice.

Figure 4.

DS Flox mice were bred with mice expressing PV-Cre (PV mice) or with mice expressing SST-Cre (SST mice). Cerebral cortical slices were prepared, PV and SST interneurons were identified by specific labeling, and APs were recorded in whole-cell current clamp mode in response to injection of the indicated amounts of depolarizing current. (a) Representative trains of action potentials recorded in whole-cell current clamp during injection of 240 pA of depolarizing current. WT, black; PV, blue. (b) Action potential number plotted vs. the level of depolarizing current. (c) Representative trains of action potentials recorded in whole-cell current clamp during injection of 160 pA of depolarizing current. WT, black; SST, yellow. (d) Action potential number plotted vs. the level of depolarizing current.