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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Curr Opin Physiol. 2017 Dec 23;2:42–50. doi: 10.1016/j.cophys.2017.12.007

Figure 5. Imbalance of excitatory vs. inhibitory neurotransmission in DS.

Figure 5.

Failure of AP firing in GABAergic interneurons in DS causes a reduction in GABA release and an imbalance of excitatory vs. inhibitory neurotransmission in circuits in the brain. This imbalance leads to epilepsy, cognitive deficit, and autistic-like behaviors plus other co-morbidities in DS.