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. 2018 Aug 7;9:855. doi: 10.3389/fphar.2018.00855

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Copyright © 2018 Wu, Yang, Wang, Zeng, Li, Liu, Guo, He, Wang, Huang, Zhou, Li, Hu, Gong and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pancreatic kallikrein administration improved the ultrastructure of diabetic cardiomyopathy in STZ-induced diabetic rats. The ultra-microstructures for arrangement of (A,B) myocardial fibers and (C) mitochondria. In the DM group, myocardial fibers, as well as mitochondria, were misarranged. Irregular arrangement of myofibrils was observed and Z lines were obscured. The mitochondrial structures showed signs of swelling and breakage of cristae. White arrows represent Z lines, myofibrils or mitochondria. However, pancreatic kallikrein (PKK) treatment reversed these pathological changes compared with the DM group.