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. 2018 Aug 7;9:855. doi: 10.3389/fphar.2018.00855

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Copyright © 2018 Wu, Yang, Wang, Zeng, Li, Liu, Guo, He, Wang, Huang, Zhou, Li, Hu, Gong and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pancreatic kallikrein administration protected against myocardial oxidative stress in STZ-induced diabetic rats. (A) Representative IHC micrographs of myocardium tissues stained with nitrotyrosine for the NDM, DM, and DM + PKK groups (original magnification × 40). The IHC scores of myocardium sections were quantified. (B) Myocardial GSH/GSSG ratio. (C–G) The mRNA expression of markers related with oxidative stress in heart tissues. (C) Nrf2, (D) SOD, (E) CAT, (F) GPx-1, and (G) GR. Each sample for qPCR was repeated for three times. Values are mean ± SEM, n = 6 per group; ^∗P < 0.05 vs. NDM group; ^#P < 0.05 vs. DM + PKK group.