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. 2018 Aug 7;9:855. doi: 10.3389/fphar.2018.00855

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Copyright © 2018 Wu, Yang, Wang, Zeng, Li, Liu, Guo, He, Wang, Huang, Zhou, Li, Hu, Gong and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pancreatic kallikrein administration protected against myocardial hypertrophy and fibrosis in the diabetic rats. (A) Representative transmission electron microscopy micrographs of myocardium tissues. White arrow indicates the accumulated collagen in the myocardial matrix. Representative images of cardiac tissue stained with (B) hematoxylin and eosin, (C) Masson (black arrow indicates the accumulated collagen in the myocardial matrix), and (D) PAS (black arrow indicates the accumulated glycogen in cardiomyocytes) for the NDM, DM, and DM + PKK groups (original magnification × 40). (E) Quantitative results of the cross-sectional diameter of myocytes within transverse cardiac sections. (F,G) Quantitative results of the cardiac extracellular matrix and collagen accumulation with Masson and PAS for the NDM, DM, and DM + PKK groups are presented (original magnification x40). Values are mean ± SEM, n = 6 per group; ^∗P < 0.05 vs. NDM group; ^#P < 0.05 vs. DM + PKK group.