Table 1.
Demographics, clinical features, and DTI indices
| Measure (mean ± SD) | Anxious depression (n=39) | Nonanxious depression (n=45) | Healthy controls (n=50) | Value | P-value |
|---|---|---|---|---|---|
| Age (years) | 26.35±6.31 | 27.27±5.88 | 27.55±5.50 | 0.634 | 0.852* |
| Education (years) | 15.84±3.12 | 15.21±3.29 | 15.52±3.23 | 0.413 | 0.664* |
| Gender (male/female) | 16/23 | 18/27 | 21/29 | 3.347 | 0.181** |
| Duration of illness (months) | 12.43±8.19 | 11.43±8.36 | – | 2.517 | 0.121*** |
| HAMD | 23.44±5.47 | 18.63±4.36 | – | 10.537 | 0.000*** |
| Adjusted HAMDa | 15.31±5.12 | 13.50±4.05 | – | 3.131 | 0.028*** |
| HAMA | 21.80±6.32 | 12.45±5.04 | – | 13.48 | 0.000*** |
| FA (mm2/s) | 0.528±0.013 | 0.659±0.017 | 0.755±0.019 | 5.675 | 0.004* |
| MD (10−4 mm2/s) | 8.581±0.217 | 8.743±0.231 | 8.622±0.224 | 1.012 | 0.365 |
| RD (10−4 mm2/s) | 6.232±0.233 | 5.751±0.265 | 5.244±0.262 | 5.041 | 0.010* |
| AD (10−3 mm2/s) | 1.121±0.022 | 1.123±0.020 | 1.128±0.023 | 0.375 | 0.708 |
Notes:
*
P-values for one-way ANOVA.
**
P-values for chi-square test.
***
P-values for two-sample t-tests.
a
Anxiety/somatization factor excluded.
Abbreviations: AD, axial diffusivity; ANOVA, analysis of variance; DTI, Diffusion Tensor Imaging; FA, fractional anisotropy; HAMA, Hamilton Rating Scale for Anxiety; HAMD, Hamilton Rating Scale for Depression; MD, mean diffusivity; RD, radial diffusivity.