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. 2018 Jul 31;2018:3817057. doi: 10.1155/2018/3817057

Figure 2.

Figure 2

miR-1907 promotes hepatocyte proliferation in vitro and in vivo. miR-1907 were overexpressed in CCL-9.1 (a) or in HL7702 (b) using miR-1907 mimics, and cell proliferation was assessed using the CCK-8 assay. miR-1907 were overexpressed in CCL-9.1 (c) or in HL7702 (d), and cell proliferation was assessed using EdU immunofluorescence staining. miR-1907 were overexpressed (e) or inhibited (f) in CCL-9.1, and cell proliferation was assessed using BrdU ELISA. (g) Immunohistochemistry analysis for PCNA showed the differences in hepatocyte proliferation between mice injected with miR-1907 and control. Original magnification ×200. Quantification of PCNA-positive cells at different timepoints after 2/3 PH was showed in (h). n=5. (i) Mice were injected with miR-1907 or control through the tail vein before and after 2/3 PH. The liver mass to body weight ratio was then calculated at different timepoint. ∗p<0.05.