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. 2018 May 29;6(3):321–344. doi: 10.1016/j.jcmgh.2018.05.009

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

NK2R antagonism prevents changes in neuromuscular transmission after colitis. (A–D) Neurogenic (A and B) contractions and (C and D) relaxations driven by EFS (20 V, 0.3 ms, 5 Hz) in colons from mice treated with vehicle or GR 159897 at 7 days after induction of colitis. (A and B) DNBS enhanced neurogenic contractions, (C and D) but did not significantly alter neurogenic relaxations. (A and B) Treatment with GR 159897 diminished the effects of DNBS colitis on neurogenic contractions (n = 3–4; 2-way analysis of variance with multiple comparisons; *P < .05; **P < .01).