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. 2018 Aug 10;11:4769–4780. doi: 10.2147/OTT.S165144

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© 2018 Yue et al. This work is published and licensed by Dove Medical Press Limited

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MSX1 was methylated in primary cervical tumors.

Notes: (A) Schematic structure of the MSX1 promoter CGI. Exon 1 (gray rectangle), CpG sites (short vertical lines), and the MSP sites analyzed are shown. The transcription start site is indicated by a curved arrow. (B) Representative MSP analysis of MSX1 methylation in primary cervical tumors, surgical margin tissues, and normal cervical tissues. (C) The expression and methylation status of MSX1 were measured in HeLa and SiHa cells treated with Aza with or without TSA by RT-PCR and MSP.

Abbreviations: CpG, 5′-C-phosphate-G-3′; CGI, CpG island; MSP, methylation-specific polymerase chain reaction; Aza, 5-Aza-2′-deoxycytidine; TSA, trichostatin A; RT-PCR, reverse transcriptase-polymerase chain reaction; M, methylated; U, unmethylated; A+T, 5-aza-2′-deoxycytidine plus trichostatin A.