Table 2.
Factors associated with postoperative recurrence in HCC
| Variables | Univariate analysis
|
Multivariate Cox analysis
|
|
|---|---|---|---|
| P-value | HR (95% CI) | P-value | |
| Age (years) | 0.011 | 0.90 (0.68–1.18) | 0.44 |
| >48 | |||
| ≤48 | |||
| Sex | 0.916 | ||
| Male | |||
| Female | |||
| HBsAg | 0.002 | 1.66 (0.98–2.80) | 0.60 |
| Positive | |||
| Negative | |||
| Edmondson | 0.861 | ||
| Low stage | |||
| High stage | |||
| AFP (ng/mL) | 0.023 | 1.46 (1.11–1.92) | 0.007 |
| >400 | |||
| ≤400 | |||
| Tumor size (cm) | 0.023 | 1.37 (1.03–1.83) | 0.031 |
| >5 | |||
| ≤5 | |||
| HBV DNA (copies/mL) | 0.045 | 0.92 (0.65–1.32) | 0.67 |
| >500 | |||
| ≤500 | |||
| Node number | <0.001 | 1.99 (1.50–2.66) | <0.001 |
| Single | |||
| Multiple | |||
| Capsule | <0.001 | 2.89 (2.15–3.90) | <0.001 |
| Absent | |||
| Complete | |||
| Cirrhosis | 0.207 | ||
| Moderate or high | |||
| Low | |||
| MVI | <0.001 | 1.80 (1.33–2.42) | <0.001 |
| Positivity | |||
| Negativity | |||
| KI-67 positive cellular index | <0.001 | 2.13 (1.62–2.80) | <0.001 |
| High | |||
| Low | |||
| Surgical margin (cm) | 0.512 | ||
| <1 | |||
| >1 | |||
Abbreviations: AFP, alpha-fetoprotein; HBsAg, serum hepatitis B surface antigen; HBV DNA, hepatitis B virus DNA levels; HCC, hepatocellular carcinoma; HR, hazard ratio; MVI, microvascular invasion.