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. 2018 Aug 10;13:4549–4561. doi: 10.2147/IJN.S170067

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© 2018 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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PK profiles in rats singly i.p. administered with various formulations at equivalent dosage of 20 mg/kg DOX and 64 mg/kg CUR.

Notes: (A) The plasma concentration–time curve of DOX. (B) The plasma concentration–time curve of CUR. (C) DOXol content in rat heart harvest 48 h after administration. **p<0.01 compared with the DOX group. All data are expressed as mean±SD of six replicates.

Abbreviations: PK, pharmacokinetic; DOX, doxorubicin; CUR, curcumin; CPMDC, complex polymeric micelles co-encapsulating DOX and CUR; DOXol, doxorubicinol.