Table 2.
Fitted PK parameters of DOX and CUR in rat plasma after single i.p. administration of with various formulations at 20 mg/kg DOX and 64 mg/kg CUR
| PK parametersa | DOX
|
CUR
|
||||
|---|---|---|---|---|---|---|
| DOX alone | Cocktail | CPMDC | CUR alone | Cocktail | CPMDC | |
| AUC0−∞ (μg⋅h/mL) | 2.40 | 2.67 | 19.9*,** | 29.0 | 54.3*** | 17.6***,** |
| CL (L/h/kg) | 8.43 | 7.51 | 1.81*,** | 2.34 | 1.21*** | 3.64***,** |
| t1/2 (h) | 4.52 | 3.48 | 69.0*,** | 15.1 | 40.4*** | 78.5***,** |
| Vd (L/kg) | 54.5 | 37.6* | 109.7*,** | 50.5 | 68.7*** | 413.0***,** |
Notes:
a
The data of six rats for each time point were used to fit with non-compartment model by DAS 2.0.
*,***,**
p<0.01 compared with the DOX alone, CUR alone and cocktail formulation, respectively.
Abbreviations: PK, pharmacokinetic; DOX, doxorubicin; CUR, curcumin; CPMDC, complex polymeric micelles co-encapsulating DOX and CUR; AUC, area under curve; CL, clearance; t1/2, half-life; Vd, volume of distribution.