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The intestinal crypt-villus axis. The small intestinal epithelium is organized into villus projections into the gut lumen and crypt invaginations into the lamina propria. Stem cells at the base of the crypt produce proliferative daughter cells that give rise to differentiated cells of the villus. Epithelial cells migrate from the proliferating compartment toward the tip of the villus where they undergo apoptosis.
