Table 4.

Baseline comorbidities and associated ICD-9-CM codes

Body system	Disease	Prevalent Chronic medications	ICD-9-CM Codes
Cardiovascular
	hypertension	B-blockers, diuretics, Ca-channel blockers, ACE-I, ARBs	4011, 4019, 4010, 40,200, 40,201, 40,210, 40,211, 40,290, 40,291, 4030, 40,300, 40,301, 4031, 40,310, 40,311, 4039, 40,390, 40,391, 4040, 40,400, 40,401, 40,402, 40,403, 4041, 40,410, 40,411, 40,412, 40,413, 4049, 40,490, 40,491, 40,492, 40,493, 40,501, 40,509, 40,511, 40,519, 40,591, 40,599, 4372
	coronary artery disease	Aspirin, ranolazine,	4110, 4111, 4118, 41,181, 41,189, 412, 4130, 4131, 4139, 4140, 41,400, 41,401, 41,406, 4142, 4143, 4144, 4148, 4149, V4581, V4582
	congestive heart failure	B-blockers, diuretics, Ca-channel blockers, ACE-I, ARBs	39,891, 4280, 4281, 42,820, 42,821, 42,822, 42,823, 42,830, 42,831, 42,832, 42,833, 42,840, 42,841, 42,842, 42,843, 4289
	atrial fibrillation	B-blockers, warfarin, Factor-X inhibitors	42,731, 42,732
Pulmonary
	chronic obstructive pulmonary disease	SABAs, LABAs, anticholinergics, inhaled corticosteroids	490, 4910, 4911, 4912, 49,120, 49,121, 49,122, 4918, 4919, 4920, 4928, 494, 4940, 4941, 496
	asthma	SABA, inhaled corticosteroids, anticholinergics	49,300, 49,301, 49,302, 49,310, 49,311, 49,312, 49,320, 49,321, 49,322, 49,381, 49,382, 49,390, 49,391, 49,392
Gastrointestinal
	gastroesophageal reflux disease	H-1 receptor blockers, proton pump inhibitors	53,081
Hematologic
	anemia	Folic acid, Iron, B-12, erythropoietin	2800, 2801, 2808, 2809, 2810, 2811, 2812, 2813, 2814, 2818, 2819, 2820, 2821, 2822, 2823, 2824, 28,240, 28,243, 28,244, 28,245, 28,246, 28,247, 28,249, 2827, 2828, 2829, 2830, 2831, 28,310, 28,311, 28,319, 2832, 2839, 2840, 28,401, 28,409, 2841, 28,412, 28,419, 2842, 2848, 28,481, 28,489, 2849, 2850, 28,521, 28,529, 2858, 2859, 2851
Endocrine/ metabolic
	hypothyroidism	Levothyroxine, liothyronine	2449
	diabetes mellitus, type 2	Oral antidiabetic medications, insulin	24,900, 25,000, 25,001, 7902, 79,021, 79,022, 79,029, 7915, 7916, V4585, V5391, V6546, 24,901, 24,910, 24,911, 24,920, 24,921, 24,930, 24,931, 24,940, 24,941, 24,950, 24,951, 24,960, 24,961, 24,970, 24,971, 24,980, 24,981, 24,990, 24,991, 25,002, 25,003, 25,010, 25,011, 25,012, 25,013, 25,020, 25,021, 25,022, 25,023, 25,030, 25,031, 25,032, 25,033, 25,040, 25,041, 25,042, 25,043, 25,050, 25,051, 25,052, 25,053, 25,060, 25,061, 25,062, 25,063, 25,070, 25,071, 25,072, 25,073, 25,080, 25,081, 25,082, 25,083, 25,090, 25,091, 25,092, 25,093
	Hyperlipidemia, dyslipidemia, hypercholesterolemia	Statins, fibrates, niacin, cholystyramine	2720, 2721, 2722, 2723, 2724, 2720, 2721, 2722, 2723, 2724
Allergy/ rheumatology
	allergic rhinitis	Intranasal corticosteroids, H1- blockers	4772, 4778, 4779
Genitourinary
	chronic kidney disease	ACE-I, ARBs	585, 5851, 5852, 5853, 5854, 5855, 5856, 5859, 7925, V420, V451, V4511, V4512, V560, V561, V562, V5631, V5632, V568
Neurologic
	seizure disorder	Anti-epileptic medication	3450, 34,500, 34,501, 3451, 34,510, 34,511, 3452, 3453, 3454, 34,540, 34,541, 3455, 34,550, 34,551, 3456, 34,560, 34,561, 3457, 34,570, 34,571, 3458, 34,580, 34,581, 3459, 34,590, 34,591, 7803, 78,031, 78,032, 78,033, 78,039
Psychiatric
	depression	SSRi, tricyclic antidepressants	311
	anxiety	SSRi, tricyclic antidepressants, benzodiazepines	29,384, 30,000, 30,001, 30,002, 30,009, 30,010, 30,020, 30,021, 30,022, 30,023, 30,029, 3003, 3005, 30,089, 3009, 3080, 3081, 3082, 3083, 3084, 3089
Musculoskeletal
	osteoarthritis	APAP, NSAIDS, opioids	71,500, 71,504, 71,509, 71,510, 71,511, 71,512, 71,513, 71,514, 71,515, 71,516, 71,517, 71,518, 71,520, 71,521, 71,522, 71,523, 71,524, 71,525, 71,526, 71,527, 71,528, 71,530, 71,531, 71,532, 71,533, 71,534, 71,535, 71,536, 71,537, 71,538, 71,580, 71,589, 71,590, 71,591, 71,592, 71,593, 71,594, 71,595, 71,596, 71,597, 71,598, V134