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. Author manuscript; available in PMC: 2019 Mar 22.
Published in final edited form as: Cell. 2018 Mar 22;173(1):20–51. doi: 10.1016/j.cell.2018.03.006

Figure 3. Comparison of Canonical and Noncanonical Biogenesis Pathways.

Figure 3

(A) The processing of canonical miRNA hairpins.

(B–D) The processing of mirtrons (B), endogenous shRNAs (C), and chimeric hairpins (D), which each feed into the canonical pathway after bypassing Microprocessor.

(E) The biogenesis of miR-451, which bypasses Dicer.

All genes are transcribed by Pol II, except as noted. Drawing conventions are as in Figure 1.