Table 4.

Subject demographics and clinical scores by TDP-43 status in definite PART

	TDP-43 Present (n = 15)	TDP-43 Absent (n = 37)	P-value
Female, N (%)	10 (67)	19 (51)	0.36
Age at clinical exam, yrs	90 [87, 92]	84 [79, 90]	0.02
Age at death, yrs	91 [90, 94]	87 [81, 91]	0.008
Post-mortem interval, hrs	13 [11, 18]	14 [7, 19]	0.58
Clinical exam to death, yrs	1.3 [0.7, 3.3]	1.0 [0.5, 2.3]	0.62
Education, yrs	12 [12, 15]	14 [12, 16]	0.21
APOE ε4 carrier, N (%)	3 (20)	1 (3)	0.07
Braak, N (%)			0.90
1	4 (27)	7 (19)
2	6 (40)	15 (41)
3	5 (33)	13 (35)
4	0 (0)	2 (5)
Hippocampal Sclerosis, N (%)	3 (20)	0 (0)	0.02
Lewy Bodies Disease, N (%)	2 (13)	1 (3)	0.20
Argyrophilic grain disease	7 (47)	9 (24)	0.11
Clinical scores
Mini-Mental State Exam score / 30	28 [27, 29]	28 [27, 29]	>0.99
CDR Sum of Boxes > 0, N(%)	1 (8)	1 (3)	0.48
WMS Logical Memory Delayed Recall / 50	13 [11, 21]	18 [12, 24]	0.93
Boston Naming / 60	55 [51, 56]	55 [51, 58]	0.56
Controlled Oral Word Association Test	50 [40, 52]	35 [25, 43]	0.13
WAIS-Block Design / 51	20 [17, 22]	18 [13, 24]	0.19
MOANS WAIS-Block Design	11 [10, 13]	10 [9, 12]	0.12
AVLT Delayed Recall / 15	8 [6, 9]	6 [4, 8]	0.10
Trails A / 180	47 [45, 93]	41 [35, 57]	0.15
MOANS Trails A	9 [5, 10]	10 [8, 12]	0.11
Trails B / 300	136 [115, 206]	112 [83, 135]	0.12
MOANS Trails B	9 [7, 10]	11 [10, 13]	0.19
Total UPDRS / 44	1 [0, 2]	0 [0, 1]	>0.99

P-values for clinical scores analysis were adjusted for age at clinical exams (n=44 cases).

Data shown as Median [quartiles] or N (%)

APOE= apolipoprotein; AVLT = auditory verbal learning test; CDR = Clinical dementia rating; WAIS-R = Wechsler Adult Intelligence Scale-Revised; WMS-R = Wechsler Memory

Scale-Revised

^¥All 3 cases with hippocampal sclerosis also had neuronal intranuclear inclusions and fine neurites of the CA1 region of the hippocampus