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. Author manuscript; available in PMC: 2018 Aug 14.
Published in final edited form as: Curr Alzheimer Res. 2017;14(6):578–585. doi: 10.2174/1567205014666170203093219

Fig. 2.

Fig. 2

ADAM10 mediated processing of AβPP in cell culture is apoE isoform dependent. In 7WCHO cells over expressing AβPP, apoE treatment (50ng/ml) for 24 hours resulted in significant differences in the expression of sAβPPα as measured by ELISA (n=3) (F (7, 16) = 22.41; p < 0.0001). ApoE4 demonstrated significantly less detectable sAβPPα compared to the apoE2-treated cells (p<0.05). Treatment with the ADAM10 specific inhibitor GI254023X significantly reduced sAβPPα formation compared to apoE2 or apoE3 alone (p<0.001) but not apoE4 alone. Data are presented as mean±SEM. Statistical significance was determined by Two-Way ANOVA followed by Sidak post-hoc analysis. *p<0.05; ** p<0.01; *** p<0.001; **** p<0.0001; ‡ comparison to non-inhibitor p<0.005.