Figure 4 -. Rosetta atomic model refinement in the cloud.
(A) WS architecture for running Rosetta model refinement across multiple VMs. (B) Run time comparisons between a local workstation (16 cores) and AWS (252 vCPUs). (C) Representative region of the cryo-EM map with the top five atomic models built by Rosetta FastRelax (D) FSC curves between the best atomic model from FastRelax and the cryo-EM map of ß- galactosidase. The resolution corresponding to the FSC value of 0.5 for the full map is shown.