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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2018 Aug;11(8):e006452. doi: 10.1161/CIRCEP.118.006452

Figure 1. Experimental protocol and development of HFpEF.

Figure 1

A. DSS rats were fed a HS or NS diet from 7 weeks of age. Echocardiography was performed to assess EF, E/A ratio and E/E’ ratio by 14-15 weeks of age. Telemetry devices were implanted to echo-proven HFpEF and control rats. Survival was monitored to identify sudden death. B. EF was preserved in HFpEF rats as well as in controls. C. E/A ratio was reduced in HFpEF rats compared to controls. D. E/E’ ratio was increased in HFpEF rats compared to controls. E. HF score was calculated from the following parameters; appearance, breathing, mobility, edema and weight. F. The HF score was increased in HFpEF rats compared to controls.