Total changes in frequency of breathing (fR), tidal volume (Vt), minute ventilation (Ve), inspiratory time (TI), expiratory time (Te) and tidal volume/inspiratory time (Vt/ Ti) upon return to room-air following exposure to either hypoxic (10% O2, 90% N2) challenge (top panel) or hypercapnic (5% O2, 21% O2, 74% N2) challenge (bottom panel) in morphine-treated sham-operated rats (SHAM) and in morphine-treated rats with bilateral carotid sinus nerve transection (CSNX) * P < 0.05, significant change from pre-hypoxia levels. †P< 0.05, CSNX versus SHAM.