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. 2018 Aug 14;13(8):e0201476. doi: 10.1371/journal.pone.0201476

Table 2. Demographic and clinical characteristics (phase 3) (n = 334).

Group 1. Healthcare Providers
(n = 124)
Group 2. Patients under OAC treatment
(n = 113)
Group 3. General public
(n = 97)
n (%) n (%) n (%)
Gender
Male 38 (30.6) 72 (63.7) 49 (50.5)
Female 86 (69.4) 41 (36.3) 48 (49.5)
Marital Status
Married 63 (50.8) 90 (79.6) 59 (60.8)
Unmarried 61 (49.2) 23 (20.4) 38 (39.2)
Nationality
Italian 124 (100.0) 109 (96.5) 97 (100.0)
Foreigners NA 4 (3.5) NA
Education
Primary school NA 44 (38.9)a 20 (20.6)
High school 27 (21.8) 58 (51.3)a 61 (62.9)
Bachelor Degree 74 (59.7) 11 (9.7)a 16 (16.5)
Post graduate 23 (18.5) NA NA
Employment
Employed 124 (100.00)* 17 (15.0) 66 (68.0)
Not employed NA 16 (14.2) 12 (12.4)
Retired NA 80 (70.8) 19 (19.6)
Type of anticoagulation treatment
DOAC NA 8 (7.1) NA
VKA NA 105 (92.9) NA
Clinical indication for anticoagulation treatment
VTE NA 17 (15.0)a NA
AF NA 70 (61.9)a NA
Heart Valve Prothesis NA 24 (21.2)a NA
PTA NA 1 (0.9)a NA
Thromboembolic or Bleeding complications §
Yes NA 6 (5.3) NA
Not NA 107 (94.6) NA
Time in treatment
≥ 3 months NA 4 (3.5) NA
≥ 6 months NA 9 (7.9) NA
≥ 12 months NA 22 (19.4) NA
≥ 36 months NA 78 (69.0) NA
Quality of anticoagulation control
TTR° 65–70% NA 45 (39.8) NA
CCI
No comorbidities NA 2 (1.7) 69 (73.4)
1–2 90 (79.6) 23 (24.4)
3–4 21 (18.5) 2 (2.1)
Mean (SD) Mean (SD) Mean (SD)
Age (years) 37.79 (10.63) 71.66 (9.86) 50.44 (17.57)

NA: Not applicable

* Health professionals: (a) Nurses (n = 118; 95.2%); (b) Physician (n = 5; 4.0%); Pharmacist (n = 1; 0.8%)

DOAC: Direct Acting Oral Anticoagulant

VKA: Vitamin K Antagonist

VTE: Venous Thromboembolism; this group also includes Ictus (n = 2; 1.8%) and Acute Myocardial Infarction (n = 2; 1.8%)

AF: Atrial Fibrillation (n = 36; 31.8%); Atrial Flutter (n = 2; 1.7%); Persistent atrial fibrillation (n = 32; 28.3%)

Heart Valve Prosthesis: includes, Mitral Valve Replacement (n = 8; 7.1%) and Aortic Valve Replacement (n = 16; 14.1%)

PTA: Percutaneous Transluminal Angioplasty

§ Thromboembolic or Bleeding complication in the last three months

° Time in Therapeutic Range (TTR) within 65–70% is a good standard of reference in the last three months

a Percentage may not reach the 100% of the category representation, due to the pairwise management of the missing values