Table 3. Association between genetic pigmentation scores of phototype and prostate and breast cancer.
| Prostate cancer | Breast cancer | ||||||
|---|---|---|---|---|---|---|---|
| SCORES | Category | Cases/Controls | OR (95% CI) | p | Cases/Controls | OR (95% CI) | p |
| GPS | All | 813/1084 | 1.01 (0.97–1.05) | 0.706 | 1133/1236 | 0.99 (0.96–1.03) | 0.637 |
| < 65 years | 341/428 | 1.05 (0.99–1.12) | 0.129 | 820/766 | 0.99 (0.95–1.03) | 0.621 | |
| ≥65 years | 472/656 | 0.97 (0.92–1.03) | 0.343 | 313/470 | 1.00 (0.94–1.08) | 0.909 | |
| BMI < 25 Kg/m2 | 205/256 | 0.96 (0.88–1.05) | 0.392 | 511/577 | 0.98 (0.93–1.04) | 0.513 | |
| BMI ≥25 Kg/m2 | 596/803 | 1.03 (0.98–1.07) | 0.297 | 551/537 | 1.00 (0.94–1.05) | 0.865 | |
| premenopausal | 403/361 | 0.98 (0.92–1.05) | 0.524 | ||||
| postmenopausal | 729/875 | 0.99 (0.95–1.04) | 0.825 | ||||
| Hair color score | All | 816/1092 | 1.01 (0.96–1.06) | 0.753 | 1138/1240 | 0.97 (0.93–1.02) | 0.265 |
| < 65 years | 341/431 | 1.02 (0.94–1.10) | 0.709 | 825/769 | 0.96 (0.91–1.02) | 0.171 | |
| ≥65 years | 475/661 | 1.00 (0.94–1.07) | 0.995 | 313/471 | 1.00 (0.92–1.09) | 0.974 | |
| BMI < 25 Kg/m2 | 206/261 | 0.96 (0.87–1.07) | 0.465 | 513/579 | 0.98 (0.92–1.04) | 0.481 | |
| BMI ≥25 Kg/m2 | 598/806 | 1.02 (0.97–1.08) | 0.458 | 554/539 | 0.97 (0.91–1.04) | 0.429 | |
| premenopausal | 404/362 | 0.99 (0.92–1.08) | 0.890 | ||||
| postmenopausal | 733/878 | 0.96 (0.91–1.02) | 0.199 | ||||
| Skin color score | All | 815/1089 | 1.00 (0.95–1.05) | 0.94 | 1136/1237 | 1.00 (0.96–1.05) | 0.901 |
| < 65 years | 341/430 | 1.02 (0.95–1.10) | 0.621 | 823/767 | 1.01 (0.95–1.06) | 0.820 | |
| ≥65 years | 474/659 | 0.98 (0.92–1.05) | 0.558 | 313/470 | 1.01 (0.92–1.10) | 0.882 | |
| BMI < 25 Kg/m2 | 206/260 | 0.92 (0.83–1.02) | 0.109 | 513/578 | 0.99 (0.93–1.06) | 0.851 | |
| BMI ≥25 Kg/m2 | 597/804 | 1.03 (0.98–1.09) | 0.262 | 552/537 | 1.01 (0.95–1.08) | 0.702 | |
| premenopausal | 404/361 | 1.02 (0.94–1.10) | 0.687 | ||||
| postmenopausal | 731/876 | 0.99 (0.94–1.05) | 0.831 | ||||
| Eye color score | All | 816/1091 | 1.01 (0.95–1.07) | 0.741 | 1136/1240 | 1.01 (0.96–1.07) | 0.574 |
| < 65 years | 341/431 | 1.05 (0.96–1.15) | 0.271 | 823/769 | 1.00 (0.94–1.07) | 0.924 | |
| ≥65 years | 475/660 | 0.98 (0.91–1.05) | 0.584 | 313/471 | 1.05 (0.95–1.15) | 0.344 | |
| BMI < 25 Kg/m2 | 206/260 | 1.00 (0.89–1.12) | 0.993 | 512/579 | 1.00 (0.93–1.08) | 0.957 | |
| BMI ≥25 Kg/m2 | 598/806 | 1.02 (0.95–1.08) | 0.623 | 553/539 | 1.03 (0.95–1.10) | 0.488 | |
| premenopausal | 404/362 | 1.01 (0.92–1.11) | 0.815 | ||||
| postmenopausal | 731/878 | 1.01 (0.95–1.08) | 0.658 | ||||
| Freckles score | All | 814/1087 | 1.00 (0.93–1.08) | 0.983 | 1135/1239 | 1.02 (0.96–1.09) | 0.514 |
| < 65 years | 341/428 | 0.98 (0.88–1.10) | 0.784 | 822/768 | 1.04 (0.96–1.12) | 0.325 | |
| ≥65 years | 473/659 | 1.00 (0.91–1.11) | 0.925 | 313/471 | 0.99 (0.88–1.12) | 0.921 | |
| BMI < 25 Kg/m2 | 205/256 | 0.94 (0.81–1.10) | 0.433 | 511/578 | 0.99 (0.91–1.09) | 0.91 | |
| BMI ≥25 Kg/m2 | 597/806 | 1.03 (0.95–1.12) | 0.481 | 553/539 | 1.05 (0.95–1.15) | 0.339 | |
| premenopausal | 403/362 | 1.01 (0.91–1.13) | 0.799 | ||||
| postmenopausal | 731/877 | 1.03 (0.95–1.11) | 0.526 | ||||
| Tanning score | All | 1108/1484 | 1.01 (0.97–1.06) | 0.596 | 1736/1906 | 0.99 (0.95–1.03) | 0.684 |
| < 65 years | 461/567 | 1.04 (0.97–1.12) | 0.29 | 1269/1170 | 0.99 (0.94–1.04) | 0.763 | |
| ≥65 years | 647/917 | 0.98 (0.92–1.05) | 0.604 | 467/736 | 1.00 (0.92–1.08) | 0.932 | |
| BMI < 25 Kg/m2 | 279/341 | 0.93 (0.84–1.02) | 0.136 | 772/847 | 0.98 (0.93–1.05) | 0.604 | |
| BMI ≥25 Kg/m2 | 810/1002 | 1.05 (0.99–1.11) | 0.109 | 834/796 | 1.00 (0.94–1.06) | 0.932 | |
| premenopausal | 611/547 | 1.00 (0.93–1.08) | 0.954 | ||||
| postmenopausal | 1124/1353 | 0.99 (0.94–1.04) | 0.628 | ||||
Model adjusted for propensity score