Figure 2. Knockout-TRIM29 enhanced the production of type I IFN and IL-6 in BMDCs and BMDMs in response to poly I:C.

(A-F) ELISA of IFN-α (A, D), IFN-β (B, E) and IL-6 (C, F) in BMDCs (A-C) or BMDMs (D-F) from wildtype (WT) and Trim29-knockout (KO) mice after 16 h of stimulation with long poly I:C (LPIC, 20 μg/ml) or short poly I:C (SPIC, 20 μg/ml) delivered by Lipofectamine 3000. Mock, cells without stimulation. *P<0.01 and **P<0.001 (unpaired t test). Data are representative of three independent experiments with similar results (mean + s.d.).