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A, In patients adoptive transfer via the regional arterial supply of the tumor (right) was hypothesized to increase exposure of adoptively transferred cells (green) to the tumor vasculature and avoid trapping in the lungs as seen with intravenous delivery (left). Adoptively transferred lymphocyte retention in the pulmonary capillaries is multifactorial (inset). B, Experimental design to examine this hypothesis in a murine model of cancer.
