TABLE 1.
Hormone levels by SLCO1B1 rs4149056 genotype and treatmenta
| Placebo | oCEE | tE2 | |||||||
| CC | CT | TT | CC | CT | TT | CC | CT | TT | |
| (n = 1) | (n = 13) | (n = 20) | (n = 0) | (n = 7) | (n = 26) | (n = 0) | (n = 4) | (n = 29) | |
| E1 | 14 | 19.23 (6.80) | 19.43 (10.46) | — | 69.71 (34.42) | 59.95 (39.49) | — | 42.00 (10.03) | 34.58 (14.64) |
| E1S | 385 | 373.62 (255.06) | 298.80 (314.05) | — | 3491 (2884.26) | 1810.58 (1348.51) | — | 1586.00 (1108.82) | 904.74 (784.91) |
| E1S/E1 | 27.5 | 18.17 (10.89) | 13.57 (7.26) | — | 50.03 (38.58) | 29.18 (15.95) | — | 35.15 (14.97) | 22.65 (12.67) |
| E2 | 3.6 | 6.37 (2.13) | 5.58 (2.61) | — | 13.76 (6.06) | 11.87 (6.85) | — | 40.25 (12.28) | 31.23 (29.09) |
| E2S | 4.9 | 7.92 (4.06) | 7.16 (4.39) | — | 43.46 (28.88) | 21.28 (16.44) | — | 56.48 (38.29) | 19.54 (13.58) |
| E2S/E2 | 1.38 | 1.26 (0.53) | 1.29 (0.32) | — | 3.40 (2.53) | 1.76 (0.85) | — | 1.64 (1.43) | 0.92 (0.51) |
CC, homozygous alleles for reduced function of enzyme; CT, heterozygous alleles; E1, serum estrone; E1S, serum estrone sulfate; E1S/E1, ratio of estrone sulfate to estrone in serum; E2, serum 17β-estradiol; E2S, serum estradiol sulfate; E2S/E2, ratio of estradiol sulfate to 17β-estradiol in serum; oCEE, oral conjugated equine estrogen; tE2, transdermal 17β-estradiol; TT, homozygous alleles for common function of enzyme.
aData are shown as mean (standard deviation).