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. 2018 Jun 14;38(8):1785–1795. doi: 10.1161/ATVBAHA.118.311168

Figure 1.

Figure 1.

Idol (inducible degrader of the low-density lipoprotein receptor) deficiency improves metabolic control on a Western-type diet (WTD). WT (wild type) and IDOL-KO (knockout) male mice were fed a 60% fat 0.2% cholesterol diet for 5 or 21 wk, as indicated (n=8–11). A and B, Total bodyweight and (C) weight of individual tissues is shown. The level of fasted plasma (D and E) glucose, (F) insulin, (G) triglycerides (H), phospholipids (I and J), and of total cholesterol and HDL (high-density lipoprotein) cholesterol is plotted. Kand L, Plasma was fractionated and cholesterol and triglyceride content of the different lipoprotein fractions determined. Each bar and error represent the mean±SEM. gWAT indicates gonadal white adipose tissue; iBAT, interscapular brown adipose tissue; lsWAT, lower subcutaneous white adipose tissue; sBAT, subscapular brown adipose tissue; usWAT, upper subcutaneous white adipose tissue; and vWAT, visceral white adipose tissue. *P<0.01, ***P<0.001, ****P<0.0001.