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. 2018 Jul 3;7:e36402. doi: 10.7554/eLife.36402

Figure 2. Interface region between two protofilaments of the α-Syn(1-121) fibril.

(A) View along the axis of the fibril as indicated by the red rectangle on the ribbon diagram (bottom right). (B) (C) Side views of the fibril with orientations indicated by arrowheads in (A) and the ribbon diagram (bottom right). Panels (B) and (C) clearly illustrate the 21 screw symmetry that results from the staggered arrangement of subunits.

Figure 2.

Figure 2—figure supplement 1. Stacking of β-strands.

Figure 2—figure supplement 1.

(A–D) Close-up side views of the α-Syn fibril illustrating homo- and hetero-steric zippers present in the structure. Pointers in the cross-section panel (top left) indicate the points of view for panels (A) to (D).