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. 2018 Aug 8;13:4509–4521. doi: 10.2147/IJN.S165184

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© 2018 Ganipineni et al. This work is published and licensed by Dove Medical Press Limited

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In vivo antitumor efficacy on survival.

Notes: (A) MRI images of the control, passive and magnetic groups before and during treatment (on day 7 and day 21, respectively). (B) Kaplan–Meier survival curves (n $ 7) of the control, passive and magnetic targeting groups. The median survival times were 44, 41 and 49 days, respectively. The magnetic targeting group showed significant differences (*p < 0.05) when compared with both the control and passive groups. PTX/SPIO-NPs, PTX/SPIO loaded PLGA-based NPs.

Abbreviations: MRI, magnetic resonance imaging; NPs, nanoparticles; PLGA, poly(lactic-co-glycolic acid); PTX, paclitaxel; SPIO, super paramagnetic iron oxide.