Table 1.
Physicochemical characterization of NPs (n ≥ 3)
| PLGA-NPs | SPIO-NPs | PTX-NPs | PTX/SPIO-NPs | |
|---|---|---|---|---|
| Size (nm) | 215 ± 4 | 225 ± 12 | 203 ± 4 | 250 ± 20 |
| PDI | 0.07 | 0.09 | 0.07 | 0.11 |
| Zeta potential (mV) | −8.6 ± 1 | −13 ± 5 | −21 ± 3 | −18 ± 5 |
| Drug encapsulation efficiency (%) | NA | NA | 31 ± 2 | 30 ± 6 |
| Drug loading (%) | NA | NA | 0.85 ± 0.3 | 0.87 ± 0.2 |
| Iron loading (%) | NA | 4 ± 1 | NA | 3 ± 1 |
Notes: physicochemical characterization of PLGA based PEGylated NPs (PLGA-NPs) loaded with either SPIO (SPIO-NPs), PTX (PTX-NPs), PTX and SPIO (PTX/SPIO-NPs).
Abbreviations: NA, not applicable; NPs, nanoparticles; PDI, polydispersity index; PLGA, poly(lactic-co-glycolic acid); PS80, polysorbate 80; PTX, paclitaxel; SPIO, super paramagnetic iron oxide.