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. 2018 Jul 20;4(8):e376. doi: 10.1097/TXD.0000000000000814

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Copyright © 2018 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Liver biopsy 16 days after nivolumab. A, HE staining illustrating prominent portal mixed inflammation with interface activity and isolated hepatocyte necrosis (yellow arrow), cytoplasmatic vacuolization of the duct epithelium consistent with bile duct damage (red arrow) and subendothelial lymphocytic inflammation with lifting up of the endothelium compatible with endothelitis (blue arrow); 400×. B, Cytokeratin-7 immunohistochemical staining highlighting the influx of inflammatory cells in the ductal epithelium associated with dysmorphic changes of the bile duct (magnification, 400×).