Table 2.
Frequency of Mutations Among Pancreatic Cancer Cases by Category of Personal and Family History of Cancer
| No. (%) of Case Patientsa | |||||
|---|---|---|---|---|---|
| Family History | |||||
| Genes | Overall (n = 3030) |
Personal History, Other Cancers (n = 513) |
Pancreatic Ductal Adenocarcinoma (n = 343) |
Breast Cancer (n = 675) |
Colorectal Cancer (n = 513) |
| ATM | 69 (2.28) | 14 (2.73) | 11 (3.29) | 18 (2.72) | 10 (1.98) |
| BARD1 | 4 (0.13) | 0 | 1 (0.30) | 0 | 0 |
| BRCA1 | 18 (0.59) | 6 (1.17) | 2 (0.60) | 4 (0.60) | 2 (0.40) |
| BRCA2 | 59 (1.95) | 14 (2.73) | 7 (2.10) | 21 (3.17) | 10 (1.98) |
| BRIP1 | 5 (0.17) | 0 | 1 (0.30) | 0 | 0 |
| CDH1 | 1 (0.03) | 0 | 0 | 0 | 0 |
| CDKN2A | 10 (0.33) | 2 (0.39) | 5 (1.50) | 2 (0.30) | 2 (0.40) |
| CHEK2 | 33 (1.09) | 9 (1.75) | 8 (2.40) | 11 (1.66) | 5 (0.99) |
| FANCC | 8 (0.26) | 2 (0.39) | 1 (0.30) | 1 (0.15) | 1 (0.20) |
| MLH1 | 5 (0.17) | 3 (0.58) | 0 | 1 (0.15) | 3 (0.59) |
| MRE11A | 2 (0.07) | 0 | 0 | 1 (0.15) | 0 |
| MSH2 | 1 (0.03) | 0 | 1 (0.30) | 1 (0.15) | 1 (0.20) |
| MSH6 | 7 (0.23) | 3 (0.58) | 1 (0.30) | 3 (0.45) | 4 (0.79) |
| NBN | 4 (0.13) | 1 (0.19) | 1 (0.30) | 1 (0.15) | 1 (0.20) |
| NF1 | 4 (0.13) | 3 (0.58) | 0 | 1 (0.15) | 1 (0.20) |
| PALB2 | 12 (0.40) | 3 (0.58) | 2 (0.60) | 5 (0.76) | 3 (0.59) |
| PMS2 | 2 (0.07) | 2 (0.08) | 0 | 1 (0.15) | 2 (0.40) |
| RAD51C | 3 (0.10) | 0 | 0 | 0 | 0 |
| TP53 | 6 (0.20) | 3 (0.58) | 2 (0.60) | 4 (0.60) | 0 |
| All genes | 253 (8.36) | 65 (12.33) | 43 (12.89) | 75 (11.31) | 45 (8.92) |
a
Number of cases in each category with amutation in the specified gene.