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. Author manuscript; available in PMC: 2018 Dec 4.
Published in final edited form as: Nat Struct Mol Biol. 2018 Jun 4;25(6):505–514. doi: 10.1038/s41594-018-0069-x

Figure 2: Dose-dependent effects of small molecule compounds on the actin-sliding velocity of β-cardiac myosin in unloaded in vitro motility.

Figure 2:

a, Structures of the compounds used in this study. The structure of omecamtiv mecarbil (OM) is reported in Malik et al. 23. b, Dose-dependent effects of the compounds on the actin-sliding velocity of human β-cardiac myosin. Velocities are normalized to the value at zero compound concentration. Note that some data points have error bars smaller than the displayed point. Error bars represent s.e.m. between two experiments, each tracking ~400 to ~1900 actin filament movements. Curves are 4-parameter logistic fits.