Skip to main content
. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Environ Toxicol Pharmacol. 2018 Jun 26;62:69–78. doi: 10.1016/j.etap.2018.06.010

Scheme 1.

Scheme 1.

A summary of the observed cell-type specific differences in PCB metabolite permeability and potential for further metabolic transformations. Colors indicate OH-PCB and PCB sulfate metabolites of PCB 3 (red), PCB 8 (black), PCB 11 (yellow), and PCB 52 (blue). A) OH-PCBs were able to enter all three cell lines tested, where B) some congeners were susceptible to sulfation in the hepatic HepG2 cells. n=3. C) All PCB sulfates were able to enter HepG2 cells, while uptake in the neural cell lines was more selective. D) Both the HepG2 and N27 cell lines exhibited sulfatase activity for some congeners, thereby resulting in in situ production of OH-PCBs.