Table 1.
Summary of EC50 values for viability of N27, SH-SY5Y, and HepG2 cells as determined by the MTT assay following 24 h exposure to PCBs or their metabolites
| PCB or Metabolite |
N27 EC50 (μM) |
SH-SY5Y EC50 (μM) |
HepG2 EC50 (μM) |
|---|---|---|---|
| PCB 3 | >50 | >50 | >50 |
| PCB 8 | >50 | >50 | >50 |
| PCB 11 | >50 | >50 | >50 |
| PCB 52 | 28.5 ± 2.4 | >50 | >50 |
| 4’-OH-PCB 3 | 31.4 ± 4.2 | >50 | >50 |
| 4-OH-PCB 8 | 13.8 ± 2.1b | 16.2 ± 0.1 | 27.0 ± 0.7b,c |
| 4-OH-PCB 11 | 15.2 ± 0.2a | 20.7 ± 0.1a | >50 |
| 4-OH-PCB 52 | 7.9 ± 0.1 a,b | 6.7 ± 0.2a,c | 13.0 ± 0.3b,c |
| 4’-PCB 3 sulfate | >50 | >50 | >50 |
| 4-PCB 8 sulfate | >50 | >50 | >50 |
| 4-PCB 11 sulfate | >50 | >50 | >50 |
| 4-PCB 52 sulfate | 14.3 ± 0.6a,b | 32.7 ± 2.2a | 28.8 ± 3.9 b |
a
Significant difference between N27 and SH-SY5Y (p<0.05)
b
Significant difference between N27 and HepG2 (p<0.05)
c
Significant difference between SH-SY5Y and HepG2 (p<0.05)