Table 2.
Summary of EC50 values for viability of N27, SH-SY5Y, and HepG2 cells as determined by LDH release following 24 h exposure to PCBs or their metabolites
| PCB or Metabolite |
N27 EC50 (μM) |
SH-SY5Y EC50 (μM) |
HepG2 EC50 (μM) |
|---|---|---|---|
| PCB 3 | >50 | >50 | >50 |
| PCB 8 | >50 | >50 | >50 |
| PCB 11 | >50 | >50 | >50 |
| PCB 52 | >50 | >50 | >50 |
| 4’-OH-PCB 3 | >50 | >50 | >50 |
| 4-OH-PCB 8 | 18.5 ± 0.4a,b | 14.0 ± 0.5a,c | 25.1 ± 2.6 b,c |
| 4-OH-PCB 11 | 22.2 ± 0.9b | 16.8 ± l.lc | 39.8 ± 4.1b,c |
| 4-OH-PCB 52 | 8.3 ± 0.6a,b | 10.2 ± 0.5a,c | 15.3 ± 0.5b,c |
| 4’-PCB 3 sulfate | >50 | >50 | >50 |
| 4-PCB 8 sulfate | >50 | >50 | >50 |
| 4-PCB 11 sulfate | >50 | >50 | >50 |
| 4-PCB 52 sulfate | >50 | 33.3 ± 2.5 | 29.2 ± 1.3 |
a
Significant difference between N27 and SH-SY5Y (p<0.05)
b
Significant difference between N27 and HepG2 (p<0.05)
c
Significant difference between SH-SY5Y and HepG2 (p<0.05)