Table 3.

Cognitive performance by anticholinergic burden.

		Total Anticholinergic Burden			Generalized linear model†
Outcome	Obs	0	1	>1	Overall	1 vs. 0	>1 vs. 0	>1 vs. 1
		(n=1223)	(n=237)	(n=98)
		M (SE)	M (SE)	M (SE)	p-value	p-value	p-value	p-value
Global NP	1556	3.3 (0.10)	3.4 (0.14)	3.6 (0.20)	0.07	0.21	0.03	0.26
Memory	1553	2.4 (0.08)	2.6 (0.12)	2.6 (0.17)	0.22	0.18	0.17	0.69
Learning	1553	2.4 (0.08)	2.7 (0.12)	3.0 (0.18)	<0.001*	0.03	0.0003	0.06
Attention/WM	1398	2.4 (0.09)	2.2 (0.11)	2.3 (0.17)	0.40	0.21	0.50	0.86
Executive Function	1540	2.8 (0.09)	2.8 (0.13)	3.3 (0.20)	0.02	0.69	0.0003	0.02
Speed	1555	2.7 (0.09)	2.8 (0.12)	2.8 (0.17)	0.78	0.63	0.56	0.83
Fluency	1550	2.6 (0.09)	2.7 (0.12)	2.7 (0.16)	0.84	0.57	0.84	0.87
Motor	1531	2.4 (0.09)	2.5 (0.13)	2.7 (0.18)	0.34	0.57	0.15	0.35

Note. Bold=significant at p<0.05. WM=working memory; NP=neuropsychological. M = estimated mean T-score; SE = standard error; OR=odds ratio.

^†controlling for HIV− and HCV status, site, current employment status, depressive symptoms, heavy drinking, smoking, marijuana, crack, cocaine and/or heroin use.

^*after controlling the false discovery rate using the Benjamini-Hochberg procedure the overall association remained significant.