Skip to main content
. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Anticancer Drugs. 2018 Sep;29(8):717–724. doi: 10.1097/CAD.0000000000000652

Figure 4. Treatment with combination of CPT-11 and 9-ING-41 leads to an increased apoptosis and a regression of SK-N-DZ xenograft tumors.

Figure 4

SK-N-DZ neuroblastoma cells were inoculated subcutaneously to 20 nude mice (1 tumor per mouse). Tumors were size matched and mice were randomized into 4 treatment groups: control (DMSO; n=5 mice), CPT-11 (5 mg/kg, n=5 mice), 9-ING-41 (70 mg/kg, n=5 mice) and CPT-11+9-ING-41 (n=5 mice). (a) Vehicle (DMSO) or drugs were injected as shown by arrows. Points, mean tumor volume; bars, SE. (b) The weight of resected tumors was measured. Columns, mean tumor weight; bars, SE. (c) Representative pictures of tumors from each group of animals. (d) The percentage of apoptotic cells was determined by TUNEL staining. Columns, mean apoptotic cells; bars, SE. (e) Representative pictures of TUNEL staining of SK-N-DZ neuroblastoma xenograft tumors treated as indicated.