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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Anesthesiology. 2018 Sep;129(3):459–476. doi: 10.1097/ALN.0000000000002281

Figure 4. Correlation of Hypnotic Potencies in Tadpoles and Zebrafish.

Figure 4

A) Zebrafish photomotor responses were reversibly inhibited by known anesthetics with potencies closely correlated to published tadpole LoRR EC50s (log[EC50] Pearson correlation r=0.999, R2=0.998, p < 0.0001). Citations for tadpole EC50s are: ethanol36, butanol36, hexanol36, ketamine37, propofol38, etomidate39, pentobarbital40, and alphaxalone42. Dexmedetomidine EC50 in tadpoles was determined by the authors. B) In a set of 5 GABAA receptor modulators displaying potent hypnotic activity in tadpole screening tests (see Table 2), a very strong correlation is observed in comparison to potencies in zebrafish (EC50 Pearson correlation r=0.9995, R2=0.999, p < 0.0001). Table 1 provides citations for the specific compounds, indicated by label number.