Table 4.
Incidence of immune cell infiltrates in Aire−/− and Aire+/+ HLA-DR2b and HLA-DR4 tg mice injected with anti-CTLA-4 + anti-CD25 and anti-CTLA-4 respectively.
| Genotype | HLA-DR2b (anti-CTLA-4 + anti-CD25) | HLA-DR4 (anti-CTLA-4) | ||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
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| Organ | Liver | Pancreas | Liver | Pancreas | ||||
|
|
|
|
|
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| CD4+ | CD8+ | CD4+ | CD8+ | CD4+ | CD8+ | CD4+ | CD8+ | |
| Aire+/+ mice | 0/4 | 0/4 | 0/4 | 0/4 | 1/3 | 0/3 | 1/3 | 0/3 |
| Aire−/− mice | 0/5 | 0/5 | 0/5 | 0/5 | 3/7 | 1/7 | 1/7 | 0/7 |
Staining was performed using AF488 anti-CD4 mAb and APC anti-CD8 mAb against a panel of organs (liver, lungs, pancreas, stomach and intestine). Shown are the incidences of mice (injected with anti-CTLA-4 and CD-25 mAb) that have immune infiltrates found in indicated organs (n = 3–7).