Whole-body MRI of a 64-year old male patient volunteer with advanced renal cell carcinoma showing improved lesion localization capability of DETECT. While both DETECT (a) and DWIBS (b) images show a left lower extremity lesion (arrows), the DWIBS image cannot localize the finding to bone, muscle or lymph node, even when zoomed in (c, arrow). However, DETECT clearly localizes the lesion within the left femur (a, d; arrows). (e) DETECT fat-only image, acquired in the same sequence, confirms the loss of normal marrow (arrow), increasing diagnostic confidence for both location and malignant nature of this lesion.